New drug delivery system based on nanoparticles for the treatment of HIV / AIDS

A researcher in biochemistry from the Miller School of Medicine at the University of Miami found that a nanoparticle-based drug delivery system can help reduce the HIV / AIDS viral reservoirs in the brain that typically lead to neurological problems.

Image Credit: Kateryna Kon / Shutterstock.com

While HIV can be managed as a chronic disease, current drugs cannot cross the blood-brain barrier. Therefore, the ability of nanoparticles to deliver antiretroviral drugs to the brain is a significant advance that could potentially improve the treatment of brain cancers and other diseases..

Shanta Dhar, PhD, Associate Professor of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami

Dhar is also deputy director of technology and innovation at the Sylvester Comprehensive Cancer Center at the Miller School of Medicine at the University of Miami.

Use of nanoparticles for drug delivery

Over the past 10 years, Dr. Dhar has investigated a polymer chain nanoparticle as a vehicle for intracellular drug delivery. Dhar’s new lab study titled “Brain-Accumulating Nanoparticles for Assisting Astrocytes to Reduce Human Immunodeficiency Virus and Drug Abuse-Induced Neuroinflammation and Oxidative Stress” was recently published in ACS Nano, a journal of the American Chemical Society.

The co-authors of the Miller School study were Bapurao surnar, PhD; Anuj S. Shah; Minseon Park, Ph.D.; Akil A. Kalathil; Mohammad Z. Kamra, PhD; and Michal Toborek, MD, PhD. The research group included Nagesh Kolishetti, PhD, as corresponding author; his student, Royden Ramirez Jaime, and Madhavan Nair, PhD, all from Herbert Wertheim College of Medicine at Florida International University.

According to Drs Dhar and Kolishetti, “Using an experimental model, we were able to use biodegradable polymer nanoparticles targeting the brain to reduce the viral load of HIV / AIDS. We’ve also included antioxidant and anti-inflammatory neuroprotectors to fight stress and inflammation in brain cells.. “

Dr Dhar observed that the administration of nanoparticle-based drugs offers a new approach for the treatment of neurocognitive disorders associated with HIV, such as dementia due to HIV, which may be amplified by recreational drug use in people. HIV positive.

For the future, this therapeutic strategy, which we have demonstrated in our laboratory, has great potential to improve the treatment of a wide range of brain diseases..

Shanta Dhar, PhD, Associate Professor of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami

Journal reference:

Nicknar, B., et al. (2021) Brain accumulation nanoparticles to help astrocytes reduce human immunodeficiency virus and neuroinflammation and oxidative stress induced by drug abuse. ACS Nano. doi.org/10.1021/acsnano.0c09553.

Source: https://med.miami.edu/


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