The University of Hong Kong School of Medicine discovered the Chinese medicine extract ‘suberect spatholobi’


The Faculty of Chinese Medicine, Li Ka Shing School of Medicine, University of Hong Kong (HKU), in collaboration with researchers from the AIDS Research Institute, Department of Microbiology, School of Medicine clinic and the State Key Laboratory of Emerging Infectious Diseases, Caulis spatholobi extract (SSP) was found to have extensive antiviral activity against SARS-CoV-1, SARS-CoV-2, influenza, and HIV-1 viruses. . More importantly, SSP has been found to largely suppress SARS-CoV-2 virus variants. Since SSP can be extracted at low cost and under quality control, and no toxicity has been found in animal studies, it has the potential to be developed as a drug to prevent the SARS-CoV-virus. 2. The results were published in Phytotherapy Research.

Nearly three years into the global coronavirus disease 2019 (COVID-19) pandemic, vaccine immunity evasion by SARS-CoV-2 virus variants poses a major challenge worldwide . However, the speed of vaccine development is not as fast as the mutation rate of the virus. Therefore, it is necessary to develop alternative response methods to stop the spread of the virus, and cost-effective antiviral agents can play a key role in epidemic control.

In this study, SSP was found to exhibit extensive inhibitory activity against SARS-CoV-1, SARS-CoV-2, H5N1 influenza virus and HIV-1 AIDS virus, and was also quite potent against SARS-CoV-2 variants. These include Alpha (B.1.1.7), Beta (B.1.351), Gamma (P1), Delta (B.1.617.2) and Omicron (BA.1, BA.2 and BA.4/5) . The active components of suberect spatholobi can adhere to the respiratory mucosa for a long time, block the ACE2 receptor on the body cells, thereby blocking the binding of the virus to the receptor on the cell membrane, blocking the invasion of the virus, and directly inhibiting the virus.

Spatholobus Suberectus Dunn (Spatholobus Suberectus Dunn) has been used for more than 20 years as a potential prophylactic agent against SARS-CoV-2, which could be used to fight the COVID-19 pandemic. Currently, there are only a few preventive medications in the world. We hope that this Chinese medicine can become a new preventive agent for the virus. She added that the mouse model was not toxic at high or low doses of SSP, so using SSP was safe.

Dr. Li Lau, Assistant Research Professor, Department of Microbiology, Faculty of Clinical Medicine and AIDS Institute, HKU School of Medicine, also pointed out, “The results demonstrate that SSP can have broad antiviral activity against different types of viruses. respiratory viral infections, preventing the virus from binding to cells. We are confident in the clinical development of SSP as different GMP validated batches have shown consistent antiviral activity.

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